Propylene glycols the propylene glycol family of chemical compounds consists of monopropylene glycol pg, dipropylene glycol dpg, and tripropylene glycol tpg. Serious intoxication may develop to coma associated with hypotonia, hyporeflexia, and less commonly seizures, and. Strategic partnership to bring disruptive technology to market maturity. Skin contact wash off immediately with soap and plenty of water removing all contaminated clothes and shoes. Always drain and flush systems containing propylene glycol with water before welding or other maintenance. Air oxidation of propylene glycol using an electrolytic crystalline silver catalyst yields pyruvic aldehyde. Propylene glycol industrial grade pgi is a colorless, odorless and slightly viscous liquid. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Mono propylene glycol is produced from propylene oxide. Management requirements for handlers and transporters introduction antifreeze is used as an engine coolant and commonly consists of ethylene glycol or propylene glycol. Propylene glycol pg uspep is a pharmacopeiaspecificationsgrade excipient of monopropylene glycol pg or mpg with a specified purity greater than 99.
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Remove contaminated, soaked clothing immediately and dispose of safely. Propylene glycol c3h8o2 cid 1030 structure, chemical names, physical and. Propylene glycol ip ch 3 propylene glycol ip ho ch 2 ch oh description pharmacopoeia. Propylene glycol 000057556 95% na dipotassium phosphate 007758114 glycol also known as hgl, 2methyl pentane2,4diol, pinakon and diolane is a clear, colourless liquid with a characteristic odour. Safety data sheet the dow chemical company product name.
Propylene glycol dinitrate results aegl program acute. Propylene glycol is a synthetic liquid substance that absorbs water. Because of its versatility propylene glycol is used in a variety of. Propylene glycol meets usp testing specifications synonym. Material safety data sheet propylene glycol 38% page 6 additional information. Propylene glycol iii update statement a technical report for propylene glycol was released in may 1993. Propylene glycol is also used to make polyester compounds and as a base for deicing solutions. It has a wide range of other practical applications, e. Ethylene glycol and propylene glycol have similar physical properties and uses. However aqueous solutions of propylene glycol greater than 22% by weight, if heated sufficiently, will produce flammable vapors. Intercool p300 is a propylene glycol based, industrially inhibited heat transfer fluid with an operating temperature range of 60f to 300f. Propylene glycol is used as a constituent in a large variety of cosmetics, and is approved and used as a vehicle for topical pharmaceutical preparations. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910. The propylene glycol family of chemical compounds consists of monopropylene glycol pg, dipropylene glycol dpg, and tripropylene glycol tpg.
Propylene glycol acute toxicity to fish material is practically nontoxic to aquatic organisms on an acute basis lc50ec50el50ll50 100 mgl in the most sensitive species tested. Propylene glycol used as an excipient european medicines agency. It is labeled an organic compound in chemistry due to its carbon attributes. Propylene glycol dipropylene glycol1 tripropylene glycol1 propylene glycols glycols chemistry centers on the two hydroxyl oh groups that characterize them as glycols. Propylene glycol is used by the chemical, food, and pharmaceutical industries as an. Propylene glycol pg has been used as a carrier in fragrance oils. Ethylene glycol is a clear, colorless, odorless, sweettasting liquid. All commercial production is via the hydrolysis of propylene oxide. It is a viscous, colorless liquid, which is nearly odorless but possesses. Show this safety data sheet to the doctor in attendance.
It has low vapor pressures at room temperature and, therefore, low potential for significant inhalation exposure. Propylene glycol dinitrate aegl technical support document pdf 79 pp, 631 k contact us to ask a question, provide feedback, or report a problem. This product is stocked in 1 gallon, 5 gallon, and 55 gallon containers in salt lake city, utah. Propylene glycol ld50 oral rat 22000 to 3 mgkgld50 dermal rabbit 2 mgkg ingestion. This edition supersedes any previously released draft or final profile or report. Propylene glycol glycol, 1,2 propandiol 57556 99 100%. It is also used in liquid preparations in pharmaceutical industry.
Propylene glycol revision date 19mar2019 sara 3112 hazard categoriessee section 2 for more information cwa clean water act not applicable clean air act not applicable osha occupational safety and health administration not applicable cercla not applicable california proposition 65 this product does not contain any proposition 65 chemicals. First aid measures general advice consult a physician. Common name 1,3butylene glycol formula c 4 h 10 o 2 cas number 107880 component cas number concentration 1,3butylene glycol 107880 99. Dow propylene glycol is a viscous, colorless, odorless liquid.
Hexylene glycol is a compound that appears in a large number of products that are used commercially and industrially. A fourth propylene glycol product, trimethylene glycol or 1,3dihydroxypropane 504632, has been available in commercial quantities in the past, but is not an important product in the 1990s 1. Propylene glycol propylene glycol nontoxic, biodegradable and virtually odorless articgard. Dec 04, 2018 systane polyethylene glycol and propylene glycol solution drops if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such. Dailymed systane polyethylene glycol and propylene glycol.
Inhibited propylene glycol based heat transfer fluid for use in secondary heating and cooling, freeze and burst protection of pipes, and various defrosting, deicing, and dehumidifying applications created date. First aid measures first aid measures eye contact rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Propylene glycol pharmacokinetics was studied following iv 4h infusion administration of 3 and 4. Pg uspep is tested for compliance with the current united states pharmacopeia usp. Chemworld boiler antifreeze is 95% inhibited propylene glycol designed to minimize corrosion while protection your system from freezing. Product codes0575 propylene glycol revision date 08jan2016 4. Certain bacterial strains convert propylene glycol to pyruvic acid in the presence of thiamine 15. Page 1 material safety data sheet propylene glycol 38%. Dow propylene glycol is used as a raw material for the manufacture of other chemicals and as an ingredient in product formulations. Propylene glycol meets usp testing specifications 1,2. Chemtrec 8004249300 outside usa 7035273887 1216 6th ave n kent wa 98032 phone.
Firstaid measures description of first aid measures do not induce vomiting. Lc50, oncorhynchus mykiss rainbow trout, static test, 96 hour, 40,6 mgl, oecd test guideline 203 acute toxicity to aquatic invertebrates propylene glycol. Dow propylene glycol uspep general description propylene glycol uspep pg uspep, referring to the united states and european pharmacopoeias, is a highpurity grade of monopropylene glycol for use in pharmaceutical, food, cosmetic, personal care, flavor and fragrance, plus a variety of other applications. Chemical product and company identification product name. Identification of the substance monopropylene glycol cas number 57556 alternative names 1. Antifreeze breaks down over time and forms acids, which corrode the vehicles cooling system. Mono propylene glycol usp this sds is not mandated under reach regulation ec no 19072006 and is provided for information only. The most common process is by the noncatalytic hydrolysis of propylene oxide in a hightemperature and highpressure environment.
Propylene glycol toxicity in children pubmed central pmc. To the best of our knowledge, the information contained herein is accurate. Never give anything by mouth to an unconscious person. Have victim rinse mouth with water, then give one to two glasses of water to drink. Propylene glycol ip grade meets the requirement of the indian it is a clear, colourless liquid, used as a solvent in the extraction of crude drugs. Product identifier product name mono propylene glycol usp product number 31055 cas number 57556 ec number 2003380 1. Propylene glycol 1, 2propanediol is an organic compound with multiple uses including. Identification of the substancemixture and of the companyundertaking 1. A guide to glycols 8 glycol is metabolized, metabolic acidosis and further central nervous system depression convulsions, muscle weakness develop.
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